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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10322110 B1

PDFFull Text
Date of Patent:
Jun. 18, 2019

Filed:

Dec. 03, 2015

Imidazole-based antimicrobial agents

Applicant:

Procomcure Biotech Gmbh, Krems, AT;

Inventors:

Kamil Önder, Salzburg, AT;

Roelf Datema, The Hague, NL;

Dale Mitchell, Essex, GB;

Ivan Kondratov, Kyiv, UA;

Assignee:

Procomcure Biotech GmbH, Thalgau, AT;

Attorney:

Dority & Manning, P.A.

Primary Examiner:

Jeffrey H Murray

Int. Cl.
CPC ...
A61K 31/4178 (2006.01); A61K 45/06 (2006.01); A61K 31/352 (2006.01); A61K 31/4164 (2006.01); A61K 31/4184 (2006.01); A61K 31/4188 (2006.01); A61K 31/4196 (2006.01); A61K 31/422 (2006.01); A61K 31/427 (2006.01); A61K 31/4192 (2006.01); C07D 403/04 (2006.01); C07D 405/04 (2006.01); C07D 409/04 (2006.01); C07D 417/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4178 (2013.01); A61K 31/352 (2013.01); A61K 31/4164 (2013.01); A61K 31/4184 (2013.01); A61K 31/4188 (2013.01); A61K 31/4192 (2013.01); A61K 31/4196 (2013.01); A61K 31/422 (2013.01); A61K 31/427 (2013.01); A61K 45/06 (2013.01); C07D 403/04 (2013.01); C07D 405/04 (2013.01); C07D 409/04 (2013.01); C07D 417/04 (2013.01); A61K 2300/00 (2013.01);
Abstract

The present invention relates to therapeutic agents suitable for use in the treatment of microbial infection in mammals. The present invention further relates to the use of pharmaceutical compositions comprising said agents in the treatment of medical conditions in mammals, in particular in the treatment of microbial infection. The agents and pharmaceutical compositions of the invention are of particular relevance in the treatment of diseases associated with antibiotic-resistant microbes. In one particular embodiment, the pharmaceutical composition can have the structural moiety of formula (I) or a pharmaceutically-acceptable salt of said compound: wherein group A is selected from the formulae Group B is aryl, Ris an optionally substituted aryl ring, an optionally substituted benzyl ring, CH, or Calkyl, and Ris hydrogen, an alkyl group, a halogen, or —(CH)N(CH)where n is an integer from 1 to 3.

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