The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 11, 2019

Filed:

Sep. 19, 2014
Applicant:

Children's Medical Center Corporation, Boston, MA (US);

Inventors:

Simon K. Warfield, Brookline, MA (US);

Benoit Scherrer, Cambridge, MA (US);

Maxime Taquet, Nivelles, BE;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01R 33/563 (2006.01); G01R 33/56 (2006.01); A61B 5/055 (2006.01);
U.S. Cl.
CPC ...
G01R 33/56341 (2013.01); A61B 5/055 (2013.01); G01R 33/5608 (2013.01); A61B 2576/026 (2013.01);
Abstract

Methods and apparatus for characterizing biological micro structure in a voxel based, at least in part, on a set of diffusion-weighted magnetic resonance (MR) data. A multi-compartment parametric model is used to predict a diffusion signal for the voxel using information from the set of diffusion-weighted MR data. Predicting the diffusion signal comprises determining, based on the set of diffusion-weighted MR data, a first set of parameters describing isotropic diffusion in a first compartment of the multi-compartment model and a second set of parameters describing anisotropic diffusion due to the presence of at least one white matter fascicle in a second compartment of the multi-compartment model. At least one first dataset of the set of diffusion-weighted MR data is associated with a first non-zero b-value and at least one second dataset of the set of diffusion-weighted MR data is associated with a second non-zero b-value different than the first non-zero b-value.


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