The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2019
Filed:
Jul. 20, 2016
Applicant:
The Uab Research Foundation, Birmingham, AL (US);
Inventors:
Donald J. Buchsbaum, Alabaster, AL (US);
Tong Zhou, Birmingham, AL (US);
Albert F. LoBuglio, Birmingham, AL (US);
Assignee:
The UAB Research Foundation, Birmingham, AL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 9/00 (2006.01); A61K 31/337 (2006.01); A61K 31/5517 (2006.01); A61K 31/704 (2006.01); A61K 47/42 (2017.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); A61K 9/0019 (2013.01); A61K 31/337 (2013.01); A61K 31/5517 (2013.01); A61K 31/704 (2013.01); A61K 39/3955 (2013.01); A61K 39/39558 (2013.01); A61K 47/42 (2013.01); C07K 2317/34 (2013.01); C07K 2317/73 (2013.01);
Abstract
Provided herein are methods of treating a subject with cancer comprising administering to the subject a death receptor agonist. Also provided herein are methods of screening a breast cancer cell for responsiveness to a DR5 agonist. Further provided herein are antibodies that selectively bind an N-terminal CARD of DDX3, a DDX3 lacking an N-terminal CARD, and an 80 kDa baculovirus TAP repeat (BIR).