The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2019
Filed:
May. 05, 2010
Sònia Guedan Carrió, Manresa, ES;
Manel Maria Cascallo Piqueras, Gelida, ES;
Ramon Alemany Bonastre, Castelldefels, ES;
Sònia Guedan Carrió, Manresa, ES;
Manel Maria Cascallo Piqueras, Gelida, ES;
Ramon Alemany Bonastre, Castelldefels, ES;
Fundacio Institut d Investigacio Biomedica de Bellvitge (IDIBELL), Barcelona, ES;
Institut Catala D Oncologia, Barcelona, ES;
Abstract
The invention is related to an oncolytic adenovirus that comprises a sequence encoding a hyaluronidase enzyme inserted in its genome. This adenovirus spreads more efficiently in the tumour mass and therefore the oncolytic effect is increased. Injecting the oncolytic adenovirus of the invention endovenously results in tumour volume regressions. Therefore, the oncolytic adenovirus of the present invention is useful for the treatment of a cancer or a pre-malignant state of cancer.