The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 11, 2019

Filed:

Jul. 22, 2014
Applicant:

Wisconsin Alumni Research Foundation, Madison, WI (US);

Inventors:

Pil Seok Chae, Madison, WI (US);

Samuel Helmer Gellman, Madison, WI (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); C07J 43/00 (2006.01); C07J 41/00 (2006.01); A61K 47/28 (2006.01); C07K 1/14 (2006.01); A61K 47/26 (2006.01); C07J 9/00 (2006.01); C07J 31/00 (2006.01); C07J 51/00 (2006.01); A61B 90/00 (2016.01); A61B 34/30 (2016.01); A61K 9/107 (2006.01);
U.S. Cl.
CPC ...
C07J 43/003 (2013.01); A61B 34/30 (2016.02); A61B 90/361 (2016.02); A61K 47/26 (2013.01); A61K 47/28 (2013.01); C07J 9/00 (2013.01); C07J 31/006 (2013.01); C07J 41/0061 (2013.01); C07J 51/00 (2013.01); C07K 1/145 (2013.01); A61B 2034/301 (2016.02); A61B 2090/3782 (2016.02); A61K 9/107 (2013.01);
Abstract

The invention provides tandem facial amphiphiles for biochemical manipulations and characterization of membrane proteins, such as intrinsic membrane proteins. Members of this new family display favorable behavior with several membrane proteins. These amphiphiles can form relatively small micelles, and small changes in amphiphile chemical structures can result in large changes in their physical properties. The tandem facial amphiphiles can be used to aid the solubilization, isolation, purification, stabilization, crystallization, and/or structural determination of membrane proteins.


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