The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2019
Filed:
Sep. 06, 2017
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Assignee:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 239/48 (2006.01); C07D 471/04 (2006.01); C07D 409/14 (2006.01); C07D 409/12 (2006.01); C07D 405/14 (2006.01); C07D 405/12 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 487/04 (2006.01); A61K 31/505 (2006.01); A61K 45/06 (2006.01); A61K 31/5377 (2006.01); A61K 31/519 (2006.01); A61K 31/517 (2006.01); A61K 31/506 (2006.01);
U.S. Cl.
CPC ...
C07D 239/48 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); Y02A 50/411 (2018.01);
Abstract
The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of EGFR, FGFR, ALK, ROS, JAK, BTK, BLK, ITK, TEC, and/or TXK and their use for the treatment of cell proliferation disorders are described.