The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2019
Filed:
Nov. 27, 2015
Applicant:
GE Healthcare As, Oslo, NO;
Inventors:
Mikkel Jacob Thaning, Oslo, NO;
Andreas Richard Meijer, Oslo, NO;
Assignee:
GE HEALTHCARE AS, Oslo, NO;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 49/10 (2006.01); A61K 49/18 (2006.01);
U.S. Cl.
CPC ...
A61K 49/108 (2013.01); A61K 49/10 (2013.01); A61K 49/18 (2013.01);
Abstract
The present invention relates to a method of preparation of formulations of gadolinium metal complexes of the macrocyclic chelator DOTA, which further comprise a small excess of free DOTA. The method uses controlled conditions such that excess gadolinium is present as a precipitate of gadolinium oxide, with filtration to remove the excess, prior to the addition of a defined excess of DOTA chelator. Also provided is a method of preparation of MRI contrast agents based on Gd-DOTA.