The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2019
Filed:
May. 17, 2016
Applicant:
Newbio Therapeutics, Inc., Shanghai, CN;
Inventors:
Nianhe Han, Shanghai, CN;
Deqiang An, Shanghai, CN;
Di Zeng, Shanghai, CN;
Baoxiang Wang, Shanghai, CN;
Hang Yang, Shanghai, CN;
Li Jian, Shanghai, CN;
Chun Yang, Shanghai, CN;
Assignee:
NewBio Therapeutics, Inc., Shanghai, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); C07D 207/452 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6889 (2017.08); A61K 47/6803 (2017.08); C07D 207/452 (2013.01); C07K 16/32 (2013.01); C07K 2317/24 (2013.01);
Abstract
A type of trimaleimide linkers and uses thereof are disclosed. The trimaleimide linkers can be applied for preparation of antibody-drug conjugate as shown by formula I: L-(T-A-D)I wherein, L is an antibody, antibody fragment or protein; T is a trimaleimide linker; A is a cleavable linker group or a noncleavable linker; D is a drug; n is an integer ranging from 1 to 8.