The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2019
Filed:
Aug. 15, 2016
Applicant:
The United States of America As Represented BY the Secretary of the Department of Health and Human Services, Washington, DC (US);
Inventors:
Michail V. Sitkovsky, Boston, MA (US);
Akio Ohta, Newton, MA (US);
Assignee:
The United States of America as represented by the Secretary of the Department of, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); A61K 39/39 (2006.01); A61K 31/00 (2006.01); A61K 31/365 (2006.01); A61K 31/519 (2006.01); A61K 31/522 (2006.01); A61K 31/53 (2006.01); A61K 31/52 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61K 31/7088 (2006.01); A61K 35/17 (2015.01); A61K 39/00 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39 (2013.01); A61K 31/00 (2013.01); A61K 31/365 (2013.01); A61K 31/519 (2013.01); A61K 31/52 (2013.01); A61K 31/522 (2013.01); A61K 31/53 (2013.01); A61K 31/7088 (2013.01); A61K 35/17 (2013.01); A61K 39/0011 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); G01N 33/5041 (2013.01); G01N 33/5055 (2013.01); A61K 2039/55561 (2013.01); G01N 2333/705 (2013.01);
Abstract
A method is provided herein to increase an immune response to an antigen. The method includes administering an agent that inhibits extracellular adenosine or inhibits adenosine receptors. Also disclosed are methods to increase the efficacy of a vaccine and to increase an immune response to a tumor antigen or immune cell-mediated tumor destruction.