The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 11, 2019

Filed:

Feb. 17, 2017
Applicant:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Inventors:

Lisa Purcell, Garnerville, NY (US);

Neil Graham, Croton-on-Hudson, NY (US);

Andrew J. Murphy, Croton-on-Hudson, NY (US);

Robert Evans, Cambridge, MA (US);

Assignee:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/02 (2006.01); C07K 16/28 (2006.01); A61K 39/395 (2006.01); C07K 16/12 (2006.01);
U.S. Cl.
CPC ...
A61K 39/099 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); C07K 16/1225 (2013.01); C07K 16/28 (2013.01); C07K 16/2866 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/57 (2013.01); A61K 2039/622 (2013.01); C07K 2317/21 (2013.01); C07K 2317/565 (2013.01); C07K 2317/70 (2013.01); C07K 2317/76 (2013.01); Y02A 50/388 (2018.01); Y02A 50/407 (2018.01); Y02A 50/412 (2018.01); Y02A 50/466 (2018.01); Y02A 50/484 (2018.01);
Abstract

The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody in combination with said vaccine. In certain embodiments, the methods of the present invention are used to afford enhanced protection to an infectious disease such as whooping cough.


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