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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10314832 B1

PDFFull Text
Date of Patent:
Jun. 11, 2019

Filed:

Dec. 27, 2017

β- and γ-diketones and γ-hydroxyketones as wnt/β-catenin signaling pathway activators

Applicant:

Samumed, Llc, San Diego, CA (US);

Inventors:

Sunil Kumar Kc, San Diego, CA (US);

David Mark Wallace, San Diego, CA (US);

John Hood, San Diego, CA (US);

Charlene F. Barroga, San Diego, CA (US);

Assignee:

Samumed, LLC, San Diego, CA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Zinna Northington Davis

Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 31/12 (2006.01); A61K 31/357 (2006.01); A61K 31/381 (2006.01); C07D 213/50 (2006.01); C07D 319/16 (2006.01); C07D 319/18 (2006.01); C07D 405/06 (2006.01); C07D 405/10 (2006.01); C07D 407/10 (2006.01); C07D 409/06 (2006.01); C07D 409/10 (2006.01); A61K 31/4402 (2006.01); A61K 31/4433 (2006.01); A61K 31/4436 (2006.01); C07C 49/784 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4436 (2013.01); A61K 9/0014 (2013.01); A61K 31/12 (2013.01); A61K 31/357 (2013.01); A61K 31/381 (2013.01); A61K 31/4402 (2013.01); A61K 31/4433 (2013.01); C07C 49/784 (2013.01); C07D 213/50 (2013.01); C07D 319/16 (2013.01); C07D 319/18 (2013.01); C07D 405/06 (2013.01); C07D 405/10 (2013.01); C07D 407/10 (2013.01); C07D 409/06 (2013.01); C07D 409/10 (2013.01);
Abstract

The present application discloses a compound which is which activates Wnt/β-catenin signaling and thus treats or prevents diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

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