The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 11, 2019

Filed:

Dec. 17, 2014
Applicant:

Dtherapeutics, Llc, San Diego, CA (US);

Inventors:

Ghassan S. Kassab, La Jolla, CA (US);

Xiao Lu, San Diego, CA (US);

Assignee:

DTherapeutics, LLC, San Diego, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/24 (2006.01); A61F 2/06 (2013.01); A61L 27/26 (2006.01); A61L 27/34 (2006.01); A61L 27/36 (2006.01);
U.S. Cl.
CPC ...
A61F 2/064 (2013.01); A61F 2/06 (2013.01); A61L 27/26 (2013.01); A61L 27/34 (2013.01); A61L 27/3604 (2013.01); A61F 2210/009 (2013.01); A61F 2210/0076 (2013.01); A61F 2220/0033 (2013.01); A61F 2220/0066 (2013.01); A61F 2220/0075 (2013.01); A61F 2220/0083 (2013.01); A61F 2310/00365 (2013.01); A61F 2310/00371 (2013.01); A61L 2420/08 (2013.01);
Abstract

The disclosure of the present application provides devices, systems, and methods for replacing damaged or compromised blood vessels and engineering luminal grafts for various medical applications. Such devices are capable of providing viable, small-diameter grafts for use in anastomotic procedures and comprise a tubular construct consisting largely of elastin and some collagen fibers and having at least one diameter of less than or equal to about 5 mm. In one exemplary embodiment, the graft comprises at least one layer of pulmonary ligament tissue and/or pulmonary visceral pleura. Systems and methods for the manufacture of the graft are also provided, which include the use of at least one layer of tissue, a mandrel and a closure mechanism.


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