The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 04, 2019

Filed:

Nov. 21, 2017
Applicant:

Biocon Limited, Bangalore, IN;

Inventors:

Pradip Nair, Bangalore, IN;

Ramakrishnan Melarkode, Bangalore, IN;

Rasika Venkataraman, Bangalore, IN;

Laxmi Adhikary, Bangalore, IN;

Ankur Bhatnagar, Bangalore, IN;

Sunaina Prabhu, Sirsi, IN;

Kriti Shukla, Ahmedabad, IN;

Dinesh Baskar, Bangalore, IN;

Saravanan Desan, Bangalore, IN;

Harish Venkatraman Pai, Bangalore, IN;

Jose Enrique Montero Casimiro, Havana, CU;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
C12P 21/005 (2013.01); C07K 16/00 (2013.01); C07K 16/2896 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/41 (2013.01); C07K 2317/54 (2013.01); C07K 2317/72 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01); Y02A 50/407 (2018.01);
Abstract

The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.


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