The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 04, 2019

Filed:

Apr. 20, 2017
Applicant:

Butamax Advanced Biofuels Llc, Wilmington, DE (US);

Inventors:

Ritu Bhalla, Tirmulgherry, IN;

Steven D. Doig, Wilmington, DE (US);

Kakasaheb Suresh Konde, Maharashtra, IN;

Ranjan Patnaik, Newark, DE (US);

Assignee:

Butamax Advanced Biofuels LLC, Wilmington, DE (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/36 (2006.01); C12P 7/16 (2006.01); C12N 15/52 (2006.01);
U.S. Cl.
CPC ...
C12N 1/36 (2013.01); C12N 15/52 (2013.01); C12P 7/16 (2013.01); Y02E 50/10 (2013.01);
Abstract

Provided herein are processes for producing an improved culture of cells comprising an engineered butanol biosynthetic pathway. The processes comprise (a) providing a cell culture of recombinant microorganisms comprising an engineered butanol biosynthetic pathway, wherein the engineered butanol biosynthetic pathway is minimal or not activated; and (b) growing the culture of recombinant microorganisms under adaptive conditions whereby pathway activation is increased to produce an improved cell culture and whereby the improved cell culture is capable of continuing to grow in fermentation.


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