The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2019
Filed:
Dec. 22, 2015
Susan Lorey, Halle/Saale, DE;
Bernhard Janowski, Halle/Saale, DE;
Heiko Pultke, Halle/Saale, DE;
Daniela Kathmann, Halle/Saale, DE;
Antje Parthier, Halle/Saale, DE;
Andreas Anton, Halle/Saale, DE;
Susan Lorey, Halle/Saale, DE;
Bernhard Janowski, Halle/Saale, DE;
Heiko Pultke, Halle/Saale, DE;
Daniela Kathmann, Halle/Saale, DE;
Antje Parthier, Halle/Saale, DE;
Andreas Anton, Halle/Saale, DE;
Wacker Chemie AG, Munich, DE;
Abstract
The present invention relates to a proNGF mutant and to uses thereof, in particular the use of a proNGF mutant for producing human beta-NGF. The present invention discloses a method of preparing a biologically active human beta-NGF from an inactive insoluble proNGF mutant. A proNGF mutant of the invention is substituted by any amino acid but not Arg or Lys at the native protease cleavage site RSKRat least at positions Rand Kcorresponding to positions 101 and 103 of the human wildtype proNGF sequence.