The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2019
Filed:
Jun. 22, 2016
Applicant:
Synbias Pharma Ag, Schaffhausen, CH;
Inventors:
Oleksandr Zabudkin, Gerusbach, DE;
Christian Schickaneder, Lauf an der Pegnitz, DE;
Iaroslav Matviienko, Mannheim, DE;
Volodymyr Sypchenko, Mannheim, DE;
Assignee:
Synbias Pharma AG, Schaffhausen, CH;
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/06 (2006.01); C07D 295/00 (2006.01); C07D 498/16 (2006.01); C07D 498/18 (2006.01);
U.S. Cl.
CPC ...
C07D 498/16 (2013.01); C07D 498/18 (2013.01);
Abstract
The present invention relates to a method for the production of a rapamycin derivative of formula (I), the method comprising the preparation of a 2-(tri-substituted silyl)oxyethyl triflate by reacting ethylene oxide and a tri-substituted silyl triflate, reaction of the resulting 2-(tri-substituted silyl)oxyethyl triflate with rapamycin in the presence of a molar excess of organic base, and deprotection to obtain the rapamycin derivative of compound (I).