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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10307691 B1

PDFFull Text
Date of Patent:
Jun. 04, 2019

Filed:

Feb. 20, 2015

Apparatus and methods for preparative liquid chromatography

Applicant:

Waters Technologies Corporation, Milford, MA (US);

Inventors:

Joshua A. Shreve, Franklin, MA (US);

Michael R. Jackson, Woonsocket, RI (US);

Assignee:

WATERS TECHNOLOGIES CORPORATION, Milford, MA (US);

Attorney:

Schmeiser, Olsen & Watts LLP

Primary Examiner:

Kara M Peo

Int. Cl.
CPC ...
B01D 15/18 (2006.01); B01D 15/16 (2006.01); B01D 15/10 (2006.01); G01N 30/32 (2006.01); B01D 15/14 (2006.01); G01N 30/26 (2006.01); G01N 30/04 (2006.01); B01D 15/12 (2006.01); G01N 30/00 (2006.01); B01D 15/08 (2006.01); G01N 30/28 (2006.01); G01N 30/02 (2006.01); G01N 30/30 (2006.01); B01D 15/00 (2006.01); G01N 30/34 (2006.01);
U.S. Cl.
CPC ...
B01D 15/18 (2013.01); B01D 15/00 (2013.01); B01D 15/08 (2013.01); B01D 15/10 (2013.01); B01D 15/12 (2013.01); B01D 15/14 (2013.01); B01D 15/16 (2013.01); B01D 15/163 (2013.01); B01D 15/166 (2013.01); G01N 30/00 (2013.01); G01N 30/02 (2013.01); G01N 30/04 (2013.01); G01N 30/26 (2013.01); G01N 30/28 (2013.01); G01N 30/30 (2013.01); G01N 30/32 (2013.01); G01N 30/34 (2013.01);
Abstract

A method of liquid chromatography includes providing one or more solvent reservoirs, providing a solvent pump, drawing one or more solvents into the pump in response to a pressure drop that promotes outgassing of the solvents, and dispersing outgassed bubbles into smaller bubbles to promote re-dissolution of the gas. A liquid-chromatography apparatus includes at least two solvent reservoirs, a pump, at least one bubble-dispersing unit that receives a pressurized flow of proportioned solvents from the pump, and a control unit. The control unit includes a processor and a memory that stores instructions; the control unit controls proportioning of solvents to obtain a preselected solvent composition, and pumping at flow rates to support preparative-scale or process-scale liquid chromatography.

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