The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2019
Filed:
Jul. 25, 2006
Laura S. Grosmaire, Hobart, WA (US);
Martha S. Hayden-ledbetter, Shoreline, WA (US);
Jeffrey A. Ledbetter, Shoreline, WA (US);
Peter A. Thompson, Bellevue, WA (US);
Sandy A. Simon, Seattle, WA (US);
William Brady, Bothell, WA (US);
Laura S. Grosmaire, Hobart, WA (US);
Martha S. Hayden-Ledbetter, Shoreline, WA (US);
Jeffrey A. Ledbetter, Shoreline, WA (US);
Peter A. Thompson, Bellevue, WA (US);
Sandy A. Simon, Seattle, WA (US);
William Brady, Bothell, WA (US);
Aptevo Research and Development LLC, Seattle, WA (US);
Abstract
The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.