The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2019
Filed:
Aug. 29, 2014
The Wistar Institute of Anatomy and Biology, Philadelphia, PA (US);
Drexel University, Philadelphia, PA (US);
Paul M. Lieberman, Wynnewood, PA (US);
Nadezhda Tikhmyanova-Eckert, Cheltenham, PA (US);
Joseph M. Salvino, Chester Springs, PA (US);
The Wistar Institute of Anatomy and Biology, Philadelphia, PA (US);
Drexel University, Philadelphia, PA (US);
Abstract
In an effort to discover therapies for treating diseases caused by EBV, a novel screening assay for identifying compounds that reactivate EBV latent infection and a family of small molecules based on a tetrahydrocarboline backbone were discovered. Specifically, the compounds have the structure of the formula (I), wherein R-Rare defined herein and activate/reactivate EBV in a variety of cell types in a patient and are, therefore, useful in preventing or treating EBV-positive cancer, optionally with an anti-viral agent. In screening these compounds, novel compositions, EBV-positive cell lines, and methods are provided. (Formula I)