The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
Sep. 02, 2016
The Trustees of Columbia University IN the City of New York, New York, NY (US);
The Research Foundation for the State University of New York, Albany, NY (US);
Arthur Mikhno, Staten Island, NY (US);
Elsa D. Angelini, New York, NY (US);
Andrew F. Laine, New York, NY (US);
Todd Ogden, Teaneck, NJ (US);
Ramin Parsey, Mountain Lakes, NJ (US);
Joseph John Mann, Riverdale, NY (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
The Research Foundation for the State University of New York, Albany, NY (US);
Abstract
The present disclosure is directed to iterative regularized reconstruction methods. In certain embodiments, the methods incorporate locally-weighted total variation denoising to suppress artifacts induced by PSF modeling. In certain embodiments, the methods are useful for suppressing ringing artifacts while contrast recovery is maintained. In certain embodiments, the weighting scheme can be extended to noisy measures introducing a noise-independent weighting scheme. The present disclosure is also directed to a method for quantifying radioligand binding in a subject without collecting arterial blood. In certain embodiments, the methods incorporate using imaging data and electronic health records to predict one or more anchors, which are used to generate an aterial input function (AIF) for the radioligand.