The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
May. 16, 2016
Applicant:
Rambam Med-tech, Haifa, IL;
Inventors:
Assignee:
RAMBAM MED-TECH, Haifa, IL;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/36 (2006.01); A61K 38/47 (2006.01); A61K 38/55 (2006.01); A61K 31/5377 (2006.01); A61K 31/727 (2006.01); A61K 38/08 (2006.01); A61K 38/10 (2006.01); A61K 38/51 (2006.01); A61K 45/06 (2006.01); G01N 33/86 (2006.01); C07K 14/81 (2006.01); C07K 14/745 (2006.01);
U.S. Cl.
CPC ...
G01N 33/86 (2013.01); A61K 31/5377 (2013.01); A61K 31/727 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61K 38/36 (2013.01); A61K 38/47 (2013.01); A61K 38/51 (2013.01); A61K 38/55 (2013.01); A61K 45/06 (2013.01); C07K 14/745 (2013.01); C07K 14/8114 (2013.01); C12Y 302/01166 (2013.01); G01N 2333/924 (2013.01);
Abstract
Methods and kits for determining heparanase procoagulant activity in a biological sample are provided. Diagnostic methods for the detection and/or monitoring of a coagulation-related pathological disorder in a mammalian subject are further provided. In addition, compositions comprising heparanase and at least one tissue factor, uses and methods based thereon in the treatment, amelioration and prevention of coagulation-related pathologic conditions are provided. Also provided are methods for screening a coagulation modulatory compound, methods and uses based thereon in the treatment, amelioration and prevention of coagulation-related pathologic conditions.