The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
Jun. 25, 2015
The General Hospital Corporation, Boston, MA (US);
David T. Ting, Dover, MA (US);
Daniel A. Haber, Chestnut Hill, MA (US);
Shyamala Maheswaran, Lexington, MA (US);
Francesca Bersani, Turin, IT;
Anders M. Naar, Arlington, MA (US);
Mihir Shivadatta Rajurkar, Worcester, MA (US);
Sakari Kauppinen, Holte, DK;
Andreas Petri, Frederiksberg, DK;
The General Hospital Corporation, Boston, MA (US);
Aalborg University, Aalborg, DK;
Abstract
Methods for treating cancer, e.g., cancer of epithelial origin, by specifically targeting human satellite II (HSATII) using sequence specific agents such as oligonucleotides. As shown herein, the hetero chromatic HSATII satellite repeat is silenced in normal cells, but massively over expressed in epithelial cancers and in cancer cell lines when grown as xenografts or in 3D culture. Induction of HSATII RNA, either in xenografts or using in vitro reconstitution models, suggests the appearance of complementary DNA intermediates.