The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
Feb. 24, 2016
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Barney Graham, Rockville, MD (US);
Wing-Pui Kong, Germantown, MD (US);
Kayvon Modjarrad, Bethesda, MD (US);
Lingshu Wang, North Potomac, MD (US);
Wei Shi, Rockville, MD (US);
Michael Gordon Joyce, Washington, DC (US);
Masaru Kanekiyo, Chevy Chase, MD (US);
John Mascola, Rockville, MD (US);
Abstract
Methods of inducing an immune response in a subject to the Middle East respiratory syndrome coronavirus (MERS-CoV) are provided. In several embodiments, the immune response is a protective immune response that inhibits or prevents MERS-CoV infection in the subject. Recombinant MERS-CoV polypeptides and nucleic acid molecules encoding same are also provided. Additionally, neutralizing antibodies that specifically bind to MERS-CoV S protein and antigen binding fragments thereof are disclosed. The antibodies and antigen binding fragments are useful, for example, in methods of detecting MERS-CoV S protein in a sample or in a subject, as well as methods of preventing and treating a MERS-CoV infection in a subject.