The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
Oct. 01, 2015
Applicant:
Protagonist Therapeutics, Inc., Milpitas, CA (US);
Inventors:
Ashok Bhandari, Pleasanton, CA (US);
Dinesh V. Patel, Fremont, CA (US);
Genet Zemede, San Jose, CA (US);
Assignee:
Protagonist Therapeutics, Inc., Newark, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 14/705 (2006.01); C07K 7/08 (2006.01); A61K 47/54 (2017.01); A61K 47/60 (2017.01); A61P 37/00 (2006.01); A61P 1/00 (2006.01); A61P 29/00 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70546 (2013.01); A61K 47/542 (2017.08); A61K 47/545 (2017.08); A61K 47/60 (2017.08); A61P 1/00 (2018.01); A61P 29/00 (2018.01); A61P 37/00 (2018.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 14/7055 (2013.01); A61K 38/00 (2013.01);
Abstract
The invention relates to C to N cyclized (C-N cyclic) monomer and dimer peptide molecules, as well as peptide dimers which are connected by linker moieties at the N terminus and the C terminus of each peptide subunit, which inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, and show high selectivity against α4β1 binding.