The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 28, 2019

Filed:

Oct. 22, 2014
Applicant:

Academia Sinica, Taipei, TW;

Inventors:

Jim-Min Fang, Taipei, TW;

Yun-Lian Lin, Taipei, TW;

Jung-Hsin Lin, Taipei, TW;

Chun-Jung Lin, Taipei, TW;

Yijuang Chern, Taipei, TW;

Nai-Kuei Huang, Taipei, TW;

Hung-Li Wang, Taipei, TW;

Benjamin Pang-hsien Tu, Taipei, TW;

Chih-Cheng Chen, Taipei, TW;

Assignee:

ACADEMIA SINICA, Taipei, TW;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/167 (2006.01); C07H 19/16 (2006.01); C07D 473/34 (2006.01); A61K 31/7076 (2006.01);
U.S. Cl.
CPC ...
C07H 19/16 (2013.01); A61K 31/7076 (2013.01); C07D 473/34 (2013.01); C07H 19/167 (2013.01); Y02P 20/582 (2015.11);
Abstract

Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N-[(3-halothien-2-yl)methyl]adenosine, N-[(4-halothien-2-yl)methyl]adenosine, and N-[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of N-[(2-bromothien-3-yl)methyl]adenosine, N-[(4-bromothien-3-yl)methyl]adenosine, N-[(5-bromothien-3-yl)methyl]adenosine N-[(2-chlorothien-3-yl)methyl]adenosine, N-[(4-chlorothien-3-yl)methyl]adenosine, and N-[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.


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