The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
Sep. 08, 2015
Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, Jiangsu, CN;
Piaoyang Sun, Jiangsu, CN;
Guaili Wu, Jiangsu, CN;
Changshan Guo, Jiangsu, CN;
Yun Lu, Jiangsu, CN;
Yuxia Wu, Jiangsu, CN;
Lingjia Shen, Jiangsu, CN;
Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, Jiangsu, CN;
Abstract
Provided are an L-proline complex of a sodium-glucose cotransporter 2 inhibitor, and a monohydrate and a crystal of the L-proline complex. Specifically, provided are 1,6-dehydrated-1-C{4-chloro-3-[(3-fluoro-4-ethoxyphenyl)methyl]phenyl}-5-C-(hydroxymethyl)-β-L-idopyranose L-proline (a compound of formula (I)), a monohydrate and a type A crystal thereof, and a preparation method therefor. The obtained type A crystal of the compound of formula (I) has good chemical stability and crystal stability, and the crystallization solvent used has low toxicity and low residue, so the type A crystal can be better used in clinical treatment.