The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 28, 2019

Filed:

Nov. 22, 2016
Applicants:

Case Western Reserve University, Cleveland, OH (US);

Board of Regents of the University of Texas System, Austin, TX (US);

University of Kentucky Research Foundation, Lexington, KY (US);

Inventors:

Sanford Markowitz, Pepper Pike, OH (US);

James K. V. Willson, Dallas, TX (US);

Bruce Posner, Richardson, TX (US);

Joseph Ready, Carrolton, TX (US);

Youngyou Zhang, Cleveland, OH (US);

Hsin-Hsiung Tai, Lexington, KY (US);

Monika Antczak, Ft. Worth, TX (US);

Stanton Gerson, Hunting Valley, OH (US);

KiBeom Bae, Buk-gu, KR;

Sung Yeun Yang, Yeonje-Gu, KR;

Amar Desai, Cleveland, OH (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4365 (2006.01); C07D 495/04 (2006.01); C07D 213/71 (2006.01); C07D 213/73 (2006.01); C07D 213/75 (2006.01); C07D 213/76 (2006.01); C07D 215/08 (2006.01); C07D 237/20 (2006.01); C07D 405/12 (2006.01); C07D 239/42 (2006.01); C07D 241/20 (2006.01); C07D 261/14 (2006.01); C07D 207/263 (2006.01); C07D 275/03 (2006.01); C07D 209/08 (2006.01); C07D 277/46 (2006.01); C07D 295/185 (2006.01); C07C 311/21 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); A61K 31/4365 (2013.01); A61K 31/519 (2013.01); C07C 311/21 (2013.01); C07D 207/263 (2013.01); C07D 209/08 (2013.01); C07D 213/71 (2013.01); C07D 213/73 (2013.01); C07D 213/75 (2013.01); C07D 213/76 (2013.01); C07D 215/08 (2013.01); C07D 237/20 (2013.01); C07D 239/42 (2013.01); C07D 241/20 (2013.01); C07D 261/14 (2013.01); C07D 275/03 (2013.01); C07D 277/46 (2013.01); C07D 295/185 (2013.01); C07D 405/12 (2013.01); C07C 2601/14 (2017.05);
Abstract

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.


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