The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
Sep. 19, 2018
Applicant:
PH Pharma Co., Ltd., Seoul, KR;
Inventors:
Vasu Jammalamadaka, Dublin, CA (US);
Sanjeev Satyal, San Carlos, CA (US);
Hoyoung Huh, Portola Valley, CA (US);
Assignee:
pH Pharma Co., Ltd., Seoul, KR;
Primary Examiner:
Int. Cl.
CPC ...
C07D 493/10 (2006.01); A61K 45/06 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 493/10 (2013.01); A61K 45/06 (2013.01); A61K 47/6803 (2017.08); A61P 35/00 (2018.01);
Abstract
The invention provides novel cytotoxic compounds and cytotoxic conjugates comprising these cytotoxic compounds and cell-binding agents. More specifically, this invention relates to novel thailanstatin A analogs, useful as cytotoxic small molecule toxins in antibody-drug conjugates (ADCs). The present invention further relates to compositions including these cytotoxic compounds and ADCs, and methods for using these toxins and ADCs to treat pathological conditions including cancer.