The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 28, 2019

Filed:

May. 28, 2009
Applicants:

Virginia I. Roxas-duncan, Fort Detrick, MD (US);

Leonard A. Smith, Fort Detrick, MD (US);

Nizamettin Gul, Fort Detrick, MD (US);

John H. Cardellina, Ii, Fort Detrick, MD (US);

Rebecca C. Vieira, Fort Detrick, MD (US);

Susan M. Ensel, Fort Detrick, MD (US);

David C. H. Yang, Washington, DC (US);

Istvan J. Enyedy, Washington, DC (US);

Sivanesan Dakshanamurthy, Washington, DC (US);

Salimuddin Shah, Washington, DC (US);

Inventors:

Virginia I. Roxas-Duncan, Fort Detrick, MD (US);

Leonard A. Smith, Fort Detrick, MD (US);

Nizamettin Gul, Fort Detrick, MD (US);

John H. Cardellina, II, Fort Detrick, MD (US);

Rebecca C. Vieira, Fort Detrick, MD (US);

Susan M. Ensel, Fort Detrick, MD (US);

David C. H. Yang, Washington, DC (US);

Istvan J. Enyedy, Washington, DC (US);

Sivanesan Dakshanamurthy, Washington, DC (US);

Salimuddin Shah, Washington, DC (US);

Assignee:

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 215/26 (2006.01); C07D 215/40 (2006.01); C07D 401/12 (2006.01);
U.S. Cl.
CPC ...
C07D 215/26 (2013.01); C07D 215/40 (2013.01); C07D 401/12 (2013.01);
Abstract

The invention provides potent quinolinol-based BoNT/A small-molecule inhibitors of botulinum neurotoxins, in particular ofserotype A neurotoxins. The invention also provides methods of using these small-molecule inhibitors to inhibit infections by, as well as, methods of preventing infections bythrough materials that may be ingested.


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