The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 28, 2019

Filed:

Jul. 24, 2017
Applicants:

Genentech, Inc., South San Francisco, CA (US);

Constellation Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Brian K. Albrecht, Cambridge, MA (US);

James Edmund Audia, Cambridge, MA (US);

Alexandre Cote, Cambridge, MA (US);

Martin Duplessis, Cambridge, MA (US);

Victor S. Gehling, Cambridge, MA (US);

Andrew Charles Good, Cambridge, MA (US);

Jean-Christophe Harmange, Cambridge, MA (US);

Yves LeBlanc, Cambridge, MA (US);

Christopher G. Nasveschuk, Cambridge, MA (US);

Alexander M. Taylor, Cambridge, MA (US);

Rishi G. Vaswani, Cambridge, MA (US);

Assignees:

GENENTECH, INC., South San Francisco, CA (US);

CONSTELLATION PHARMACEUTICALS, INC., Cambridge, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 211/39 (2006.01); C07C 211/38 (2006.01); C07C 211/17 (2006.01); C07C 211/19 (2006.01); A61K 31/137 (2006.01); A61K 31/136 (2006.01); A61K 31/135 (2006.01); A61K 31/4465 (2006.01); C07C 211/42 (2006.01); C07D 231/12 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 211/78 (2006.01); C07D 213/38 (2006.01); C07C 255/58 (2006.01); C07C 217/74 (2006.01); C07C 229/50 (2006.01); C07C 237/48 (2006.01); A61K 31/166 (2006.01); A61K 31/196 (2006.01); A61K 31/277 (2006.01); A61K 31/337 (2006.01); A61K 31/351 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/415 (2006.01); A61K 31/4155 (2006.01); A61K 31/437 (2006.01); A61K 31/4406 (2006.01); A61K 31/445 (2006.01); A61K 31/4545 (2006.01); A61K 31/4747 (2006.01); A61K 31/495 (2006.01); A61K 31/517 (2006.01); A61K 45/06 (2006.01); C07C 317/36 (2006.01); C07D 205/04 (2006.01); C07D 205/12 (2006.01); C07D 207/06 (2006.01); C07D 211/26 (2006.01); C07D 211/46 (2006.01); C07D 215/08 (2006.01); C07D 295/185 (2006.01); C07D 305/08 (2006.01); C07D 309/04 (2006.01);
U.S. Cl.
CPC ...
C07C 211/42 (2013.01); A61K 31/135 (2013.01); A61K 31/166 (2013.01); A61K 31/196 (2013.01); A61K 31/277 (2013.01); A61K 31/337 (2013.01); A61K 31/351 (2013.01); A61K 31/397 (2013.01); A61K 31/40 (2013.01); A61K 31/415 (2013.01); A61K 31/4155 (2013.01); A61K 31/437 (2013.01); A61K 31/445 (2013.01); A61K 31/4406 (2013.01); A61K 31/4545 (2013.01); A61K 31/4747 (2013.01); A61K 31/495 (2013.01); A61K 31/517 (2013.01); A61K 45/06 (2013.01); C07C 217/74 (2013.01); C07C 229/50 (2013.01); C07C 237/48 (2013.01); C07C 255/58 (2013.01); C07C 317/36 (2013.01); C07D 205/04 (2013.01); C07D 205/12 (2013.01); C07D 207/06 (2013.01); C07D 211/26 (2013.01); C07D 211/46 (2013.01); C07D 211/78 (2013.01); C07D 213/38 (2013.01); C07D 215/08 (2013.01); C07D 231/12 (2013.01); C07D 295/185 (2013.01); C07D 305/08 (2013.01); C07D 309/04 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2603/94 (2017.05);
Abstract

Provided herein are compounds of formula I: and salts thereof and compositions and uses thereof. The compounds are useful as inhibitors of LSD1. Also included are pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various LSD1-mediated disorders.


Find Patent Forward Citations

Loading…