The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
Jun. 02, 2017
Alcyone Lifesciences, Inc., Lowell, MA (US);
Eric Leuthardt, Lowell, MA (US);
P J Anand, Lowell, MA (US);
Alcyone Lifesciences, Inc., Lowell, MA (US);
Abstract
Drug delivery devices and methods are disclosed herein. In some embodiments, a drug can be delivered into a brain ventricle of a subject, where it can diffuse, flow, or otherwise travel across the ependyma and into the hippocampus. The drug can be delivered through a delivery device configured to selectively or transiently obstruct a portion of the ventricle, e.g., the temporal horn or a posterior portion of the temporal horn. The obstruction can define a partitioned volume of the ventricle, limiting or preventing flow of cerebrospinal fluid (CSF) into or out of the partitioned volume. Accordingly, a drug can be delivered into the partitioned volume without being diluted or carried away by CSF, allowing the drug to saturate the ependyma adjacent the hippocampus. The delivery device can allow a high concentration of drug to be achieved and/or maintained within the partitioned volume to enable maximal transependymal penetration to the hippocampus, while reducing the volume of drug needed to achieve a desired therapeutic effect and limiting delivery of the drug to non-targeted areas.