The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 28, 2019

Filed:

Sep. 17, 2014
Applicants:

The Regents of the University of California, Oakland, CA (US);

Devacell, Inc., San Diego, CA (US);

Inventors:

Inanc Ortac, San Diego, CA (US);

Sadik C. Esener, Solana Beach, CA (US);

Ibrahim Gokce Yayla, Del Mar, CA (US);

Bradley Messmer, San Diego, CA (US);

Assignees:

The Regents of the University of California, Oakland, CA (US);

Devacell, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61K 9/51 (2006.01); C12Q 1/00 (2006.01); C12Q 1/30 (2006.01); C12Q 1/54 (2006.01); A61B 5/145 (2006.01); A61K 38/50 (2006.01); A61K 49/00 (2006.01); A61K 49/22 (2006.01); A61B 5/1455 (2006.01);
U.S. Cl.
CPC ...
A61K 49/0093 (2013.01); A61B 5/1455 (2013.01); A61B 5/14532 (2013.01); A61B 5/6831 (2013.01); A61B 5/7278 (2013.01); A61K 9/5115 (2013.01); A61K 49/225 (2013.01); C12Q 1/00 (2013.01); C12Q 1/30 (2013.01); C12Q 1/54 (2013.01); A61B 2503/40 (2013.01); A61K 38/50 (2013.01);
Abstract

Disclosed are methods, systems, and devices for implementing nanoparticles to encapsulate biomolecules such as enzymes. In one aspect, a nanoparticle device includes a shell structure including an internal layer structured to enclose a hollow interior region and include one or more holes penetrating through the internal layer, and an external layer formed of a porous material around the internal layer; and an enzyme contained within the interior region of the shell structure, the enzyme having entered the shell structure through the one or more holes and incapable of passing through the external layer, in which the pores are of a size that prevents the enzyme to pass through the pores while permitting substances smaller than the pore size to pass through the pores.


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