The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
Jul. 14, 2017
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Darrell J. Irvine, Arlington, MA (US);
Eric Dane, Cambridge, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/51 (2006.01); A61K 47/64 (2017.01); C07K 19/00 (2006.01); C08G 69/10 (2006.01); A61K 47/68 (2017.01); C07K 14/00 (2006.01); A61K 47/54 (2017.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
A61K 47/6425 (2017.08); A61K 9/5123 (2013.01); A61K 47/542 (2017.08); A61K 47/543 (2017.08); A61K 47/64 (2017.08); A61K 47/645 (2017.08); A61K 47/6807 (2017.08); A61K 47/6911 (2017.08); C07K 14/003 (2013.01); C08G 69/10 (2013.01); C07K 19/00 (2013.01);
Abstract
The present disclosure provides a synthetic nanoparticle comprising a peptide nucleic acid (PNA) oligomer conjugated to a lipid, wherein the PNA oligomer noncovalently complexes with an immunomodulatory compound, thereby forming a nanoparticle. The nanoparticles are useful to elicit immune responses and can be used to treat a broad range of cancers and infectious diseases.