The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 28, 2019

Filed:

Sep. 03, 2015
Applicants:

Board of Regents, the University of Texas System, Austin, TX (US);

Baylor College of Medicine, Houston, TX (US);

Inventors:

Beth C. Levine, Dallas, TX (US);

Sanae Shoji-Kawata, Dallas, TX (US);

Nick V. Grishin, Dallas, TX (US);

Lisa N. Kinch, Dallas, TX (US);

Olivier Lichtarge, Houston, TX (US);

Angela D. Wilkins, Houston, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2019.01); C07K 14/47 (2006.01); C07K 14/82 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
A61K 38/08 (2013.01); C07K 7/06 (2013.01); C07K 14/47 (2013.01); C07K 14/4747 (2013.01); C07K 14/82 (2013.01);
Abstract

An autophagy-inducing compound comprises an autophagy-inducing peptide comprising Beclin 1 peptides immediately N- and C-terminally flanked by moieties Rand R, respectively, wherein up to six of said peptide residues may be substituted, Rand Rdo not naturally flank the Beclin 1 residues, and F270 and F274 are optionally substituted and optionally linked. The compounds may be used to induce autophagy.


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