The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
Dec. 26, 2014
Applicant:
Samyang Biopharmaceuticals Corporation, Seoul, KR;
Inventors:
Joong-Woong Cho, Daejeon, KR;
Gyeong-Hae Kim, Daejeon, KR;
Min-Hyo Seo, Daejeon, KR;
Sa-Won Lee, Daejeon, KR;
Assignee:
SAMYANG BIOPHARMACEUTICALS CORPORATION, Seoul, KR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
B01D 19/00 (2006.01); C02F 1/20 (2006.01); C02F 1/22 (2006.01); A61K 31/519 (2006.01); A61K 9/19 (2006.01); A61K 9/08 (2006.01); A61K 47/26 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 9/08 (2013.01); A61K 9/19 (2013.01); A61K 47/26 (2013.01);
Abstract
Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing oxygen during the preparation without use of an antioxidant. The method is readily applicable for manufacturing by freezing and degassing in a sealed chamber, and can provide formulations with significantly increased stability for the unstable drug against oxidation.