The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2019
Filed:
Dec. 07, 2011
Bruce Seligmann, Tucson, AZ (US);
BJ Kerns, Tucson, AZ (US);
John Luecke, Tucson, AZ (US);
Matt Rounseville, Tucson, AZ (US);
Ihab Botros, Tucson, AZ (US);
Mark Schwartz, Tucson, AZ (US);
Bruce Seligmann, Tucson, AZ (US);
BJ Kerns, Tucson, AZ (US);
John Luecke, Tucson, AZ (US);
Matt Rounseville, Tucson, AZ (US);
Ihab Botros, Tucson, AZ (US);
Mark Schwartz, Tucson, AZ (US);
HTG Molecular Diagnostics, Inc., Tucson, AZ (US);
Abstract
Disclosed herein are methods of detecting presence of a gene fusion in a sample from a subject. In some embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize a fusion probe that spans the point of fusion between two nucleic acids or genes, and detecting the fusion probe after nuclease treatment. In other embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize two or more probes that flank the point of fusion between two nucleic acids or genes, and detecting these probes after nuclease treatment. In additional embodiments, the methods can include determining the percentage of gene fusion in the sample relative to the first nucleic acid or the second nucleic acid.