The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2019
Filed:
Aug. 16, 2012
Applicants:
Hua Shi, Ithaca, NY (US);
Daiying Xu, Quincy, MA (US);
Vamsee Krishna Chatakonda, Albany, NY (US);
Inventors:
Assignee:
The Research Foundation for The State University of New York, Albany, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/115 (2010.01); C07K 14/72 (2006.01);
U.S. Cl.
CPC ...
C12N 15/115 (2013.01); C07K 14/721 (2013.01); C12N 2310/16 (2013.01); C12N 2310/51 (2013.01); C12N 2330/51 (2013.01);
Abstract
The present invention relates to a nucleic acid aptamer molecule that includes a domain that binds to an estrogen receptor, molecular complexes that include the nucleic acid aptamer molecule and an estrogen receptor, and constructed DMA molecules and expression systems, as well as host cells, that the contain an RNA aptamer molecule of the invention. Use of these aptamers and encoding constructs to inhibiting estrogen receptor activity in a cell and to treat estrogen receptor-positive cancers is also described.