The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2019
Filed:
Jul. 06, 2018
Eli Lilly and Company, Indianapolis, IN (US);
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Stephen J Demarest, San Diego, CA (US);
Xiufeng Wu, San Diego, CA (US);
Raheleh Toughiri, San Diego, CA (US);
Brian Arthur Kuhlman, Chapel Hill, NC (US);
Steven Morgan Lewis, Chapel Hill, NC (US);
Eli Lilly and Company, Indianapolis, IN (US);
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Abstract
The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (V/V) domain and the heavy chain-light chain constant (C/C] domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.