The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 21, 2019

Filed:

Aug. 03, 2015
Applicants:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA (US);

Inventors:

David B. Weiner, Merion, PA (US);

Bernadette Ferraro, La Jolla, CA (US);

Jian Yan, Wallingford, PA (US);

Patricia A. Brown, Magnolia, TX (US);

Rodney A. Bowling, Austin, TX (US);

Douglas R. Kern, The Woodlands, TX (US);

Mathura P. Ramanathan, Ardmore, PA (US);

Niranjan Y. Sardesai, Blue Bell, PA (US);

Karuppiah Muthumani, Cherry Hill, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); C07K 14/005 (2006.01); A61K 39/12 (2006.01); A61K 39/00 (2006.01); A61K 39/135 (2006.01); A61K 39/39 (2006.01); A61M 37/00 (2006.01); A61N 1/32 (2006.01); G01N 33/569 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/12 (2013.01); A61K 39/135 (2013.01); A61K 39/39 (2013.01); A61M 37/00 (2013.01); A61N 1/327 (2013.01); C12N 7/00 (2013.01); G01N 33/56983 (2013.01); A61K 2039/523 (2013.01); A61K 2039/53 (2013.01); A61K 2039/552 (2013.01); C12N 2770/32122 (2013.01); C12N 2770/32134 (2013.01); G01N 2333/09 (2013.01); G01N 2469/20 (2013.01);
Abstract

Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.


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