The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 21, 2019

Filed:

Dec. 01, 2016
Applicant:

The Florida State University Research Foundation, Inc., Tallahassee, FL (US);

Inventors:

Hedi Mattoussi, Tallahassee, FL (US);

Naiqian Zhan, Tallahassee, FL (US);

Goutam Palui, Tallahassee, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 271/22 (2006.01); C07D 339/04 (2006.01); A61K 49/00 (2006.01); C09K 11/02 (2006.01); C09K 11/58 (2006.01); C09K 11/88 (2006.01); G01N 33/53 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
C07D 339/04 (2013.01); A61K 49/00 (2013.01); C07C 271/22 (2013.01); C09K 11/025 (2013.01); C09K 11/58 (2013.01); C09K 11/883 (2013.01);
Abstract

A series of multicoordinating and multifunctional ligands optimized for the surface-functionalization of luminescent quantum dots (QDs) and gold nanoparticles (AuNPs) alike is disclosed. An L-aspartic acid precursor is modified with functionality, through simple peptide coupling chemistry, one or two lipoic acid (LA) groups and poly(ethylene glycol) (PEG) moieties in the same ligand. These ligands were combined with a new photoligation strategy to yield hydrophilic and reactive QDs that are colloidally stable over a broad range of conditions, including storage at nanomolar concentration and under ambient conditions.


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