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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10293060 B1

PDFFull Text
Date of Patent:
May. 21, 2019

Filed:

Feb. 19, 2016

Method for increasing expression of rna-encoded proteins

Applicant:

Curevac Ag, Tübingen, DE;

Inventor:

Patrick Baumhof, Dusslingen, DE;

Assignee:

CureVac AG, Tübingen, DE;

Attorney:

Parker Highlander PLLC

Primary Examiner:

Antonio Galisteo Gonzalez

Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 9/00 (2006.01); C07K 14/005 (2006.01); C07K 14/505 (2006.01); C12N 7/00 (2006.01); C12N 9/02 (2006.01); C12N 15/67 (2006.01); C12N 15/68 (2006.01); C12N 15/88 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0075 (2013.01); A61K 9/0021 (2013.01); A61K 48/0066 (2013.01); A61K 48/0083 (2013.01); C07K 14/005 (2013.01); C07K 14/505 (2013.01); C12N 7/00 (2013.01); C12N 9/0069 (2013.01); C12N 15/67 (2013.01); C12N 15/68 (2013.01); C12N 15/88 (2013.01); A61K 38/00 (2013.01); C12N 2760/00034 (2013.01); C12N 2760/20134 (2013.01); C12Y 113/12007 (2013.01); Y02A 50/402 (2018.01); Y02A 50/415 (2018.01); Y02A 50/423 (2018.01);
Abstract

The invention relates to an RNA comprising at least one open reading frame (ORF) and comprising at least one modification, which increases the expression of the encoded peptide or protein. Furthermore, the invention relates to the medical use of such a modified RNA administered to a subject by jet injection. The invention relates further to a pharmaceutical composition and to a kit of parts comprising said modified RNA for administration by jet injection, preferably for use in the field of gene therapy and/or genetic vaccination. Additionally, the invention relates to a method for enhancing the (localized) expression of RNA-encoded peptides or proteins in the dermis or muscle (of a mammal) comprising administering the modified RNA by jet injection. And finally, the invention relates to a method of treatment comprising administering the modified RNA by jet injection to a subject in need thereof.

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