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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10293031 B1

PDFFull Text
Date of Patent:
May. 21, 2019

Filed:

Oct. 15, 2014

Compositions and methods for promoting the mineralization of biological tissue

Applicant:

New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery, New York, NY (US);

Inventors:

Matthew E. Cunningham, Manhasset, NY (US);

Agata Krzyzanowska, Brooklyn, NY (US);

Assignee:

NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY, New York, NY (US);

Attorney:

Leason Ellis LLP

Primary Examiner:

Maria Marvich

Int. Cl.
CPC ...
A61P 19/02 (2006.01); A61K 48/00 (2006.01); A61K 38/16 (2006.01); C12N 5/10 (2006.01); C12N 15/12 (2006.01); C07K 14/525 (2006.01); C07K 14/545 (2006.01); A61K 38/46 (2006.01); C07K 14/47 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01); A61K 9/00 (2006.01); A61K 31/195 (2006.01); A61K 31/675 (2006.01); A61K 31/7076 (2006.01); A61K 31/7088 (2006.01); A61K 31/713 (2006.01); A61K 35/32 (2015.01); C12N 5/077 (2010.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 38/465 (2013.01); A61K 9/0019 (2013.01); A61K 9/0085 (2013.01); A61K 31/195 (2013.01); A61K 31/675 (2013.01); A61K 31/7076 (2013.01); A61K 31/7088 (2013.01); A61K 31/713 (2013.01); A61K 35/32 (2013.01); A61K 38/191 (2013.01); A61K 38/2006 (2013.01); A61K 39/00 (2013.01); A61K 45/06 (2013.01); A61K 48/00 (2013.01); A61L 27/3658 (2013.01); A61L 27/3687 (2013.01); A61L 27/3821 (2013.01); A61L 27/3856 (2013.01); A61L 27/3895 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); C07K 14/4702 (2013.01); C12N 5/0655 (2013.01); C12N 15/1138 (2013.01); A61L 2300/412 (2013.01); A61L 2300/45 (2013.01); A61L 2300/604 (2013.01); A61L 2300/64 (2013.01); A61L 2400/06 (2013.01); A61L 2430/38 (2013.01); C12N 2310/122 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2320/31 (2013.01); C12N 2320/32 (2013.01); C12N 2501/2301 (2013.01); C12N 2501/73 (2013.01); C12Y 301/03001 (2013.01);
Abstract

This invention relates to compositions and methods for activating and promoting mineralization in tissue that does not normally mineralize, specifically intervertebral discs. The composition comprises agents that increase the expression of the gene that encodes TNAP and/or the activation, amount or activity of TNAP protein, and agents that decrease the expression of ANK and/or ENPP and/or the activation, amount or activity of these proteins. The composition can be in the form of a cell or cells. The invention also relates to methods of using the composition.

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