The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2019
Filed:
Mar. 11, 2016
Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Lianyungang, CN;
Hubo Wang, Lianyungang, CN;
Xueyan Zhu, Lianyungang, CN;
Meng Guo, Lianyungang, CN;
Mingtong Hu, Lianyungang, CN;
Jiasong Zhang, Lianyungang, CN;
Jiude Sun, Lianyungang, CN;
Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Jiangsu, CN;
Abstract
The present invention relates to a nintedanib diethanesulfonate salt A-type crystal represented by formula (II), and also relates to a crystalline composition and pharmaceutical composition comprising the crystal, and preparation method and use thereof. An X-ray powder diffraction spectrum of the nintedanib diethanesulfonate salt A-type crystal of the present invention has a diffraction peak at about 14.64, 18.79, 19.31, 20.11, 21.20, 22.45 and 26.71° when represented via a 2θ value. The nintedanib diethanesulfonate salt A-type crystal of the present invention has a stable property, is non-hygroscopic and difficult to degrade, and is particularly suitable for medicine production.