The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 21, 2019

Filed:

Jun. 27, 2017
Applicant:

Duke University, Durham, NC (US);

Inventors:

Adam Wax, Chapel Hill, NC (US);

John W. Pyhtila, Durham, NC (US);

Assignee:

Duke University, Durham, NC (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01B 9/02 (2006.01); G01J 3/45 (2006.01); A61B 5/00 (2006.01); G01N 21/31 (2006.01); G01N 21/47 (2006.01); A61B 1/00 (2006.01);
U.S. Cl.
CPC ...
A61B 5/0084 (2013.01); A61B 1/00165 (2013.01); A61B 1/00172 (2013.01); A61B 5/0075 (2013.01); G01B 9/0209 (2013.01); G01B 9/02043 (2013.01); G01B 9/02044 (2013.01); G01B 9/02084 (2013.01); G01B 9/02087 (2013.01); G01B 9/02091 (2013.01); G01J 3/45 (2013.01); G01N 21/31 (2013.01); G01N 21/4795 (2013.01); A61B 5/0066 (2013.01); G01N 2021/4704 (2013.01); G01N 2021/4709 (2013.01); G01N 2021/4735 (2013.01); G01N 2201/08 (2013.01);
Abstract

A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.


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