The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 21, 2019

Filed:

Nov. 05, 2012
Applicant:

Wisconsin Alumni Research Foundation, Madison, WI (US);

Inventors:

Helen Blackwell, Middleton, WI (US);

Reto Frei, Ecublens, CH;

Anthony Breitbach, Madison, WI (US);

David M. Lynn, Middleton, WI (US);

Adam H. Broderick, Midland, MI (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/52 (2006.01); C07D 235/30 (2006.01); A61K 31/416 (2006.01); A61K 45/00 (2006.01); C07D 235/02 (2006.01); A61K 31/4184 (2006.01);
U.S. Cl.
CPC ...
A01N 43/52 (2013.01); A61K 31/416 (2013.01); A61K 31/4184 (2013.01); A61K 45/00 (2013.01); C07D 235/02 (2013.01); C07D 235/30 (2013.01);
Abstract

Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those ofand more particularly


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