The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 14, 2019

Filed:

Jun. 24, 2015
Applicant:

Case Western Reserve University, Cleveland, OH (US);

Inventors:

Kevin D. Cooper, Cleveland, OH (US);

Thomas S. McCormick, Cleveland, OH (US);

David S. Soler, Cleveland, OH (US);

Andrew Young, Cleveland, OH (US);

Assignee:

CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); G01N 33/574 (2006.01); G01N 33/564 (2006.01); C12N 15/113 (2010.01); C12Q 1/6886 (2018.01); A61K 31/70 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57484 (2013.01); C12N 15/113 (2013.01); C12Q 1/6886 (2013.01); G01N 33/564 (2013.01); G01N 33/57488 (2013.01); C12N 2310/14 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); G01N 2800/50 (2013.01);
Abstract

A method for diagnosing an increased risk of a cancer in a subject includes the steps of obtaining a blood sample from the subject and determining, in the blood sample, a level of two or more of the polypeptides selected from the group consisting of VNN2, KCNJ15, SERPINB2, CREB5, ICAM3, NFE2, MNDA, PXN, FCAR, TSHZ3, NRG1, ALOX5AP, PAD14, PAD12, QPC, VNN1, SERPINB10, CLEC4D, TREM1, CLEC4E, CD82, MGAM, TMEM45B and VNN3, wherein an increase in the level of two or more of the polypeptides compared to a control level is indicative of an increased risk of cancer in the subject.


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