The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2019
Filed:
Apr. 30, 2010
Applicants:
Alessandra Biffi, Milan, IT;
Bernhard Rudolf Gentner, Milan, IT;
Luigi Naldini, Milan, IT;
Inventors:
Assignees:
Ospedale San Raffaele S.r.l., Milan, IT;
Fondazione Telethon, Rome, IT;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); C12N 15/113 (2010.01); C12N 15/86 (2006.01); C12N 15/11 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/111 (2013.01); A61K 48/00 (2013.01); C12N 2310/141 (2013.01); C12N 2310/51 (2013.01); C12N 2320/32 (2013.01); C12N 2330/51 (2013.01); C12N 2799/027 (2013.01);
Abstract
A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell.