The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2019
Filed:
Jun. 29, 2016
Applicant:
General Electric Company, Schenectady, NY (US);
Inventors:
Vandana Keskar, Schenectady, NY (US);
Weston Blaine Griffin, Niskayuna, NY (US);
Xiaohua Zhang, Niskayuna, NY (US);
Assignee:
General Electric Company, Schenectady, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 3/00 (2006.01); C12N 5/077 (2010.01); C12M 1/34 (2006.01); C12M 1/00 (2006.01); G01N 3/08 (2006.01); G01N 35/04 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0655 (2013.01); C12M 21/08 (2013.01); C12M 23/26 (2013.01); C12M 41/40 (2013.01); C12M 41/46 (2013.01); G01N 3/08 (2013.01); G01N 35/04 (2013.01); G01N 2035/0465 (2013.01);
Abstract
The present approach relates to the design and use of a functionally closed bioreactor designed to immobilize, culture, and mature tissue on a loading platform. The bioreactor may be equipped with sensors for tissue monitoring which in conjunction with stiffness data can provide closed-loop control of tissue maturation. Based on a relationship between cartilage stiffness and tissue maturity, measurements of stiffness can be acquired and used as a surrogate for cartilage maturity without the need for destructive tests.