The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2019
Filed:
Sep. 28, 2015
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Inventors:
Dimiter S. Dimitrov, Frederick, MD (US);
Weizao Chen, Frederick, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/10 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); A61K 38/17 (2006.01); A61K 39/42 (2006.01); C07K 14/73 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 16/1045 (2013.01); A61K 38/1774 (2013.01); A61K 39/42 (2013.01); A61K 47/6841 (2017.08); C07K 14/70514 (2013.01); C07K 16/005 (2013.01); C07K 16/1063 (2013.01); C07K 16/2812 (2013.01); C07K 2317/21 (2013.01); C07K 2317/32 (2013.01); C07K 2317/53 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/569 (2013.01); C07K 2317/76 (2013.01); C07K 2317/94 (2013.01); C07K 2319/35 (2013.01);
Abstract
The invention provides single domain antibodies and derivatives thereof that bind antigens of interest, which are stable, soluble, and do not tend to aggregate. The invention also provides methods for constructing a dAb library and methods for screening dAb libraries to identify the dAb of the invention. The invention also provide methods of treating or preventing conditions by antigen neutralization by administering the dAbs of the invention.