The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2019
Filed:
Feb. 13, 2015
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Adam R. Renslo, Oakland, CA (US);
Erica M. W. Lauterwasser, Wachenheim, DE;
Shaun D. Fontaine, Walnut Creek, CA (US);
Benjamin B. Spangler, San Francisco, CA (US);
James A. Wells, Burlingame, CA (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 323/02 (2006.01); A61K 31/357 (2006.01); C07H 19/16 (2006.01); C07F 7/18 (2006.01); C07D 407/12 (2006.01); C07D 405/14 (2006.01); C07D 405/12 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 471/14 (2006.01); C07D 493/04 (2006.01); C07D 519/04 (2006.01); C07F 9/655 (2006.01); C07H 19/06 (2006.01); C07H 19/167 (2006.01); A61K 31/4025 (2006.01); A61K 31/404 (2006.01); A61K 31/4192 (2006.01); A61K 31/427 (2006.01); A61K 31/435 (2006.01); A61K 31/437 (2006.01); A61K 31/444 (2006.01); A61K 31/4709 (2006.01); A61K 31/4745 (2006.01); A61K 31/496 (2006.01); A61K 31/4985 (2006.01); A61K 31/513 (2006.01); A61K 31/662 (2006.01); A61K 31/7072 (2006.01); A61K 31/7076 (2006.01); A61K 31/7135 (2006.01); A61K 51/04 (2006.01); C07D 487/04 (2006.01); C07D 491/107 (2006.01); C07D 491/113 (2006.01); C07D 491/153 (2006.01); C07D 493/14 (2006.01); C07K 7/06 (2006.01); A61K 47/64 (2017.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07H 19/16 (2013.01); A61K 31/357 (2013.01); A61K 31/404 (2013.01); A61K 31/4025 (2013.01); A61K 31/4192 (2013.01); A61K 31/427 (2013.01); A61K 31/435 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/4709 (2013.01); A61K 31/4745 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/513 (2013.01); A61K 31/662 (2013.01); A61K 31/7072 (2013.01); A61K 31/7076 (2013.01); A61K 31/7135 (2013.01); A61K 47/64 (2017.08); A61K 47/6803 (2017.08); A61K 51/0459 (2013.01); C07D 323/02 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 407/12 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/14 (2013.01); C07D 487/04 (2013.01); C07D 491/107 (2013.01); C07D 491/113 (2013.01); C07D 491/153 (2013.01); C07D 493/04 (2013.01); C07D 493/14 (2013.01); C07D 519/04 (2013.01); C07F 7/1804 (2013.01); C07F 9/65517 (2013.01); C07H 19/06 (2013.01); C07H 19/167 (2013.01); C07K 7/06 (2013.01); C07B 2200/05 (2013.01); Y02A 50/411 (2018.01);
Abstract
Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5]decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.